{"id":8704,"date":"2013-06-18T06:10:28","date_gmt":"2013-06-18T06:10:28","guid":{"rendered":"https:\/\/acneeinstein.com\/?p=1183"},"modified":"2018-11-03T11:36:12","modified_gmt":"2018-11-03T11:36:12","slug":"minocycline-hyperpigmentation","status":"publish","type":"post","link":"https:\/\/acneeinstein.com\/minocycline-hyperpigmentation\/","title":{"rendered":"Long-Term Minocycline Treatment May Turn Your Skin Blue"},"content":{"rendered":"

OK, sorry about the sensational headline, I just couldn\u2019t resist. Especially since there\u2019s a grain of truth to it. I just came across case reports and papers reporting skin hyperpigmentation after minocycline treatment. These describe people who have developed blue\/gray areas on their skin following minocycline treatment. Apparently this not so common but also not rare side-effect has been known since 1978.<\/p>\n

What does it look like<\/h2>\n

Here are two cases that developed around acne scars, apparently this sort of hyperpigmentation can develop even after fairly short treatments (more on that later).<\/p>\n

\"minocycline-hyperpigmentation\"<\/a><\/p>\n

Source: A new type of minocycline-induced cutaneous hyperpigmentation<\/a><\/p>\n

Here\u2019s another case that developed for an older man who took minocycline for rheumatoid arthritis.<\/p>\n

\"minocycline-hyperpigmentation-2\"<\/a><\/p>\n

Source: Minocycline-induced hyperpigmentation: comparison of 3 Q-switched lasers to reverse its effects<\/a>.<\/p>\n

As you can see from the image on the left, most of the face is covered with dark patches. The image on the right shows more normal looking skin, after laser treatment.<\/p>\n

Here\u2019s yet another case.<\/p>\n

\"drug_induced_hyperpigmentation-7\"<\/a><\/p>\n

Source: Drug-induced Hyperpigmentation<\/a><\/p>\n

In short, it\u2019s not pretty. I\u2019m not sure which one is worse, this or acne.<\/p>\n

When does this happen?<\/h2>\n

The good news is that these side-effects are not that common. The bad news is that there\u2019s no clear relationship between treatment dosage and duration and occurrence of hyperpigmentation.<\/p>\n

Here are some things we can say:<\/p>\n