Adrenal Fatigue Or Not?

Adrenal Fatigue Or Not?

I’ve been bothered by adrenal fatigue. Scratch that. I’ve been bothered by the concept of adrenal fatigue, not the so-called disease itself. The whole thing has always smelled little too much ‘alternative medicine’ to me. All the information comes from sources not exactly dedicated to critical thinking and scientific enquiry, with most medical organizations and more reliable sources either denying the concept or being silent about it.

But I’ve never bothered to investigate it in detail as hasn’t seem that relevant. Anyway, I recently saw an article at titled Have Adrenal Fatigue? No You Don’t (link broken :(). The article calls adrenal fatigue as ‘the most bogus concepts in health’. I could think of several other contestants to that dubious title, but I digress. Anyway, I decided to write a quick article based on what Danny wrote in his article.

I’ll return to why Danny Rodin’s article soon, but let’s first look at what adrenal fatigue is.

What is adrenal fatigue?

Let me ask you a few questions:

  • Feel tired often?
  • Having trouble getting up in the morning?
  • Feel little too dependent on coffee?
  • Feeling stressed and run down?

Then you may have adrenal fatigue! <sarcasm>Congratulations, you are just like everyone else on this planet!</sarcasm> claims that all the above are symptoms of adrenals not being able to meet the demands life puts on them. Basically, you have too much stress (physical and/or psychological) and it wrecks your adrenals, and as a result they can’t maintain proper hormonal balance, which then causes you to feel tired and lethargic.

The disease was invented in 1998 by Dr. James Wilson. He also popularized it with his book Adrenal Fatigue: The 21st Century Stress Syndrome. Despite not being recognized by the medical community, adrenal fatigue is estimated to affect 80% of the population.

That alone rises several red flags in my head, such as 1) invented by a single doctor, 2) who decided to write a book about it instead of vetting the concept with the scientific community in scientific journals (as is the proper thing to do with new discoveries), 3) affects just about everyone. Wikipedia also says it’s nonsense, and not to be confused with adrenal insufficiency, a real medical condition.

It seems to be yet another ‘disease’ designed to heap quilt on us for living a modern lifestyle. For example, has an article about adrenal fatigue, and in the article there’s a description of people likely to be affected by it:

Those who are: students, medical professionals, single parents, unhappily married, unhappy or unsatisfied at work, are self-employed or starting a new business, abuse drugs or alcohol, have alternating shift schedules or who are the “all work and no play” types have lifestyles that lead to adrenal fatigue. Furthermore, life events that can lead to adrenal fatigue include: unrelieved pressure or stress at work, any crisis or severe emotional trauma, death of a loved one, major surgery, extended or chronic illness, sudden change in life situations such as loss of a job or moving without much friend or family support in a new location and repeated or extended chemical exposure.

Can you find yourself in that? Of course you can – just about any person living in a modern society fits that description. Heck, I could argue that almost every single person on the earth could identify with that.

Problems with adrenal fatigue concept

There are two things that just about everyone talking about adrenal fatigue agree on:

  • Stress causes damage to adrenals and weakens adrenal function over time
  • Adrenal issues are related to cortisol dysfunction (either too much or too little cortisol)

According to Danny Rodin there are problems with both of these assumptions.

  • No adrenals? No problem! I have to confess I didn’t look at all the studies Danny referenced, but he brings up several studies that show how resilient the adrenal glands are. Researchers have literally ‘scooped out’ everything inside the adrenal capsule, yet the remaining cells have regenerated quickly to produce working adrenals. Instead of adrenals being weak, as characterized by the proponents, they seem to be extremely resilient.
  • Adrenal fatigue is often diagnosed by testing salivary cortisol levels. Yet, salivary hormone tests are highly unreliable and often show no relationship with hormone levels in blood. Furthermore, there are several, non-stress related reasons for elevated cortisol levels. For example, hormones such as estrogen, serotonin, and prolactin all increase cortisol levels. So while cortisol is thought to be a stress hormone, it also has several other functions in the body. It’s also released when the body creates glucose from protein and other substances. So people who limit carbohydrate intake will show higher levels of cortisol.

I should say that I don’t claim to be an expert on adrenal fatigue. It’s certainly possible that it is a real disease and a real problem and will be recognized by the medical community in due time. But there are several problems with the whole concept. The disease ticks most of the boxes bogus disease list, such as being invented by a single doctor, fuzzy diagnostic guidelines (often diagnosed with a questionnaire), little to no information in scientific journals, and claimed to be an undiagnosed epidemic affecting almost everyone. Add to that the points Danny made about resiliency of adrenal glands, and you have a good reason to be skeptical and not wasting a lot of money on adrenal support supplements and herbs.

But I feel like crap, what should I do?

Honest answer is that I don’t know. Health issues are complex, and I don’t have all the answers. I don’t think that anyone denies that stress, overworking, and overtraining are bad for you, but perhaps feeling fatigued is just that. You have overextended yourself. Perhaps we don’t need to invent a new disease to explain it. Perhaps it’s normal to have ups and downs in energy levels, and the whole concept of feeling super energized every day is probably just a fantasy.

But based on what I’ve read online, here are some things I would do:

  • Reduce carbohydrates somewhat and focus more on fat.
  • Try paleo-style diet that limits (or even excludes) most grains. I suspect they are on to something with grains causing gut, and perhaps even autoimmune, problems for some people. And those things can drain your energy levels.
  • Take some time to relax and de-stress every day, 10 minutes a day is plenty.
  • Make sure you eat your fruits and vegetables.
  • Be physically active, but push yourself too hard.
  • Get enough sleep.
  • Remember to take time off from work/studies to just relax.

Common sense? Yes, most science-based recommendations are.

So what does this have to do with acne? Nothing, as such. I just presume that many people looking for answers to acne run into adrenal fatigue sooner or later.

About Me

Hi, I am Acne Einstein(a.k.a. Seppo Puusa). I'm a bit of a science nerd who is also passionate about health. I enjoy digging through medical journals for acne treatment gems I can share here. You can read more about my journey through acne and how I eventually ended up creating this.


2 thoughts on “Adrenal Fatigue Or Not?”

  1. Seppo,

    I recently read an article myself on adrenal fatigue being the cause of spots. According to the article this was caused by a sodium/potassium imbalance in the body. That imbalance in turn was affected by the magnesium/zinc ratio in the body. I’m not sure how many scientific studies the theory was based on but the author was so sure in their presentation. Again the imbalances created our old friends toxins that had to be expelled via the skin. I would be more in tune with this if somehow the imbalances were related to sebum production etc. But no, it was toxins that was the culprit. That does not explain why the mineral imbalances come about in the first place and why for some it leads to spots and for others it does not. The article also said that acne was not caused by hormones but by the mineral imbalance

    • Unfortunately I don’t have enough background medical knowledge to comment on the mineral ratios. It sounds like one of those alt-med scienc-y sounding articles where they add some scientifically sounding terms and sentences to give the impression that they know what they are talking about. Laypeople have no way of saying whether those scienc-y bits are correct, but for someone who understands the field the statements are laughable.

      What I can say is that anytime you encounter someone claiming toxins cause acne (or any other disease for that matter), you can stop reading. Because you are dealing with a ‘mindless drone’ who’s just parroting the alt-med party line. Yes, chemicals and ‘toxins’ can cause some diseases, but doctors and scientists usually wouldn’t use such ambiguous terms like ‘toxins’, they would refer to the specific substance known to cause the problem.

      It’s fairly well established that hormones do affect acne, even if we can’t absolutely say that they cause acne. There are several lines of evidence pointing to that conclusion. I talked about these in Clear for Life, but from the top of my head:

      – In vitro studies show that sebocytes and keratinocytes respond to androgens and insulin/IGF-1
      – Sebacious glands in acne-prone skin have more androgen receptors than those on a normal skin
      – People who have problems processing androgen/IGF-1 signals rarely develop acne. For example, people without androgen receptors almost never get acne. Same goes for Laron syndrome patients, people with very low IGF-1 levels.
      – External testosterone or IGF-1 usually leads to acne, such as testosterone abuse by bodybuilders, androgen treatment in female -> male sex changes and IGF-1 in Laron syndrome.
      – Diets that lower insulin (and thus also IGF-1 and androgens) have been shown to reduce acne.
      – Drugs that reduce insulin (metformin) or affect sex hormones (birth control pills) usually reduce acne.

      So when someone claims hormones don’t affect acne, it just says how ignorant they are.

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