How Genes Affect Acne And How To Mitigate The Damage

By Seppo | Cause

DNA strand

How much of acne is genetic? And how much of it is under your control? In this post we’ll try to answer these questions. I’ll also explain how genes contribute to acne, and what you can do to mitigate the damage.

Studies: Acne is strongly genetic

The relative contribution of genes and environment on acne has been studies quite a few times. Let’s look at some of these studies.

  • A massive study of 458 pairs of identical twins and 1099 pairs of fraternal twins found that genes explained 81% of the difference in acne prevalence. Only 19% was explained by non-shared environmental factors (such as diet and stress).
  • One study looked at the influence of genes on sebum production. This study had 20 pairs of each identical and fraternal twins. Identical twins had almost identical sebum excretion rates but different rates of acne severity. Fraternal twins had different rates of sebum production and acne severity. They concluded that sebum production, but not acne severity, is under genetic control (a conclusion I disagree somewhat with).
  • One study compared 204 acne patients with 144 non-acne controls. The researchers compared the difference in rates of acne in first-degree relatives (parent, sibling, and offspring) between patients and controls. They found that having a first-degree relative with acne increases your risk of getting it by 4 times.

From these studies it’s clear that genes have a prominent role in acne. I know that these studies paint a grim picture, and I hope you don’t take a fatalistic view of this. Because these studies don’t give you the whole picture. There’s another side to the coin also.

  • Dr. Cordain found no evidence for acne in the more tribal societies he studied. Similarly acne is less prevalent in nonwestern countries, but when people from those countries migrate to West they often develop acne.
  • Similarly studies on diet and acne have found that low sugar and low GI diets reduce or even completely acne.

What these (and countless other) studies show that genes are not destiny. Having ‘acne genes’ doesn’t mean you automatically get it, or that there’s nothing you can do about it. What genes do is make it more likely that you get acne, given certain environmental influences (more on that later).

I believe the studies on the heredity of acne overemphasize the importance of genes. Why? Simply because family members often eat and do similar things. So if you have similar genes and eat similar foods, it’s no wonder you find similar rates of acne. And these studies can’t capture the kind of dietary changes that help acne.

The point is that, yes, genes contribute to acne, but they aren’t the whole story and having acne genes doesn’t doom you.

What ‘acne genes’ do?

What genes do is they increase your propensity to develop acne. They modify the physiology of your skin to be more sensitive to hormones and other factors. For example:

  • Genes influence how sensitive your skin is to hormones. So that similar levels of androgen hormones have different effects on acne-prone and healthy skin. And because of this acne-prone skin produces more sebum and has faster rate of skin cell growth.
  • Genes influence the strength of inflammatory response to bacteria. It’s known that acne patients have far stronger inflammatory response to P. Acnes bacteria and other minor injuries.
  • Genes also influence the production of anti-inflammatory chemicals in the skin.

And because of factors like those you get acne and some other people don’t, even if you have identical diets, lifestyle and other environmental factors.

We can mitigate the damage

Now because of advances in medical research we now know many natural ways of mitigating the damage genes do to your skin. Consider these examples:

  • Green tea can block the androgen receptors in the skin and reduce the damage those hormones do to the skin. That’s why studies show dramatic reduction in sebum production after using green tea cream.
  • Similarly caffeine can dampen the pro-inflammatory effect androgen hormones have on the acne-prone skin.

Are these enough to completely mitigate the effect of ‘acne genes’? Probably not, but every little bit helps. And those little bits start adding up when you really know what you are doing.

Importance of acceptance

Meet Elizabeth. She’s a fictional character that illustrates something I’ve seen over and over in my years of working with acne patients.

Elizabeth is in her 30s and has suffered from acne since her teen years. Understandably she’s frustrated. Nothing has really worked for her. She has tried all the creams and lotions. She has tried many diets. She has cleansed and detoxed. She’s been to homeopath and other natural doctors. She feels like she’s at the end of the road and desperate because nothing seems to help.

She’s stressed. She reads everything about acne she can get her hands on. And the frustration piles up with every failure. She has lost count on how much money she has spent on different remedies and treatments.

Can you identify with Elizabeth?

If so, we should face a somber truth. Because acne is a strong genetic factor it may be possible you won’t get over it completely. I’m not saying you shouldn’t do anything about it, but I think it’s important to face that as a possibility.

And it’s even more important to accept what can’t be changed.

Here’s why I think it’s one of the best things you can do for your skin and life. Humans are emotional creatures. I don’t claim to know your situation, but in general we humans do things for emotional reasons. And the vast majority of acne patients want to get clear because of the emotional pain acne causes.

So it’s not acne as such that’s the problem, it’s the emotional pain that it causes. You may think you can’t separate them, but you can. I believe there are two reasons why acne is so painful for some people:

  1. They believe it means something negative about them (like they are dirty or somehow broken).
  2. Stress and frustration caused by repeated failures. They want to get over it, but they can’t.

But those two things are not set in stone. And they are not tied to acne. You can work on yourself, and figure out what having acne means to you. And with some work you can come to realize that it doesn’t have to mean anything negative about you.

Similarly, practicing acceptance can cut out lot of the stress acne and trying to get over it causes.

Learn to accept what is. Deal with it. And suddenly it’s not such a big deal anymore.

Very rarely acne limits your life in any real way. You can find examples of people acne succeeding in any endeavor. Even celebrities and high-profile actors have acne.

Again, I’m not advocating a fatalistic view. And I’m not saying you shouldn’t try to cure your acne. What I’m saying is that, I believe, it’s far better to work on acceptance than mindlessly going down the path that leads to more frustration and wasted time and money. The stress alone can perpetuate acne.

Summary and take-home messages

Acne is strongly influenced by genes, and having a first-degree relative with acne increases your risk of getting acne by 4 times. While genes as such don’t cause acne they change the physiology of your skin in a way that makes you more likely to develop acne. They make you far more sensitive to dietary and other environmental influences.

With combination of internal and external treatments you can mitigate the effect of genes and in many cases completely clear your acne. So while you can’t change the hand you were dealt with, it’s important you play that hand well.

But there exists a real possibility that you may not completely get over your acne. And that’s why it’s importance to practice acceptance, and you to identify and work on the reasons that make acne so painful. This work alone can make a profound difference not only in the quality of your life but also on your skin.


About the Author

Seppo Puusa, a.k.a. AcneEinstein shares rational advice about natural and alternative acne treatments. Read more about me and my acne struggles at the page.

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